An important thrust area is Chemical Biology which combines the fields of synthetic chemistry, molecular biology, and molecular imaging, to create novel chemical tools for probing biological systems. Visualizing bio-molecules in vivo allows early non-invasive diagnosis and more importantly brings forth most sought insights into disease onset mechanisms. Our department has a unique confluence of teams working on synthetic chemistry, materials, and spectroscopy focusing on developing new optical imaging techniques. This allows us to bring in synthetic chemistry insights to develop strategic chemical probes for molecular imaging and also test them for in vivo imaging applications. Another approach for imaging crucial biomarkers is to directly visualize bio-molecules in a label-free manner. We have been able to directly excite neurotransmitters with multiphoton excitation, and have been able to observe their dynamics in living cells and in brain tissue.